Mikulicz’s Disease With Immune Thrombocytopenia: A New Immunoglobulin G4-Mediated Disorder and Literature Review

Shu LI, Cong DENG, Jinwei CHEN, Fen LI

Department of Rheumatology and Immunology, The Second Xiangya Hospital, Central South University, Changsha, China

Keywords: Immunoglobulin G4-related disease, Mikulicz’s disease, thrombocytopenia

Abstract

Mikulicz’s disease (MD), an immunoglobulin G4 (IgG4)-related disease, is a fibrosis-associated inflammatory disease characterized by painless bilat- eral swelling of lacrimal and salivary glands. Although thrombocytopenia is associated with many rheumatologic disorders, it is rare in IgG4-related MD. This novel study aims to report a rare case of IgG4-related MD complicated with severe autoimmune thrombocytopenia without any hemato- logical malignancies and review all cases of IgG4-related disease associated with thrombocytopenia in the literature.

Citation: Li S, Deng C, Chen J, Li F. Mikulicz’s disease with immune thrombocytopenia: a new immunoglobulin g4-mediated disorder and literature review. Arch Rheumatol 2019;34(x):i-v.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Financial Disclosure

This work was supported by grants from the National Natural Science Foundation of China Youth Fund (No. 81302567).