A Cross Sectional Study of the Impact of Human Immunodeficiency Virus, Hepatitis B Virus and Hepatitis C Virus on Rheumatoid Factor Production

Etienne Atabonkeng PHILÉMON1, Christopher TUME1, Marie Claire OKOMO ASSOUMOU2, Salomon TCHUANDOM BONSI1, Ikomey Mondide GEORGES2, Hervé OUAMBO FOTSO3, Lyonga EMILYA2, Mesembe Tonga MARTHA2, Madelaine NGANDEU-SINGWE2

1Department of Biochemistry, University of Dschang, Dschang, Cameroon
2University of Yaounde I, Faculty of Medicine and Biomedical Sciences, Yaounde, Cameroon
3University of Buea, Faculty of Health Sciences, Buea, Cameroon

Keywords: Human immunodeficiency virus, prevalence, rheumatoid factor, viral hepatitis

Abstract

Objectives: This study aims to investigate how human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV) affect the production of immunoglobulin M (IgM)-rheumatoid factor (RF).
Patients and methods: The study included 405 voluntary participants (139 males, 266 females; mean age 39.4±17.9 years; range 3 to 88 years) randomly recruited by a consecutive sampling technique in the main health facilities of the Center, East, Far North, Littoral and West regions of Cameroon. We excluded persons under treatment or hospitalized for any form of primary autoimmune disease. Blood samples were collected and used for serological analyses. We sought for the HIV antibodies (Ab); the core antibody (HBcAb), the surface antigen (HBsAg), and the replicative antigen (HBeAg) of the HBV; HCVAb of HCV and the IgM-RF.
Results: The prevalence of HIVAb was 7.61%, 38.7% for HBcAb, 5.43% for HBsAg, 1.26% for HBeAg and 6.41% for IgM-RF in the study population. The Far North region had the highest prevalence of IgM-RF (9.8%) and the Littoral region had the lowest prevalence (3.2%). The prevalence of RF was 6.7% and 5.7% for females and males, respectively (sex ratio of 2.25). The IgM-RF prevalence was 9.7%, 8.9%, 9.1%, and 27.8% in participants with positive serological results for HIVAb, HBcAb, HBsAg, and HCV, respectively.
Conclusion: Infection by HIV and HBV showed to poorly stimulated IgM-RF production. However, IgM-RF was highly produced in HCV infected participants. Increased IgM-RF production may contribute to cytotoxicity in tissues or organs of HCV-infected patients, leading to the onset of autoimmune diseases.

Citation: Philémon EA, Tume C, Okomo Assoumou MC, Tchuandom Bonsi S, Georges IM, Ouambo Fotso H, et al. A cross sectional study of the impact of human immunodeficiency virus, hepatitis B virus and hepatitis C virus on rheumatoid factor production. Arch Rheumatol 2018;33(4):402-407.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Financial Disclosure

The authors received no financial support for the research and/or authorship of this article.