Prediction of subclinical left ventricular dysfunction by speckle-tracking echocardiography in patients with anti-neutrophil cytoplasmic antibody--associated vasculitis
Tuba Nur İzgi1
, Dilek Barutcu Ataş2, Halil Ataş3, Dursun Akaslan3, Can Ilgın4, Arzu Velioğlu2, Hakkı Arıkan2, Fatma Alıbaz-Öner5, Haner Direskeneli5, Serhan Tuğlular2, Ebru Aşıcıoğlu2
1Department of Internal Medicine, Marmara University, Faculty Medicine, Istanbul, Turkey
2Department of Nephrology, Marmara University, Faculty Medicine, Istanbul, Turkey
3Department of Cardiology, Marmara University, Faculty Medicine, Istanbul, Turkey
4Department of Public Health, Marmara University, Faculty Medicine, Istanbul, Turkey
5Department of Rheumatology, Marmara University, Faculty Medicine, Istanbul, Turkey
Keywords: Anti-neutrophil cytoplasmic antibody-associated vasculitis, cardiovascular risk, speckle-tracking echocardiography, strain.
Abstract
Objectives: This study aims to evaluate left ventricular functions using speckle-tracking echocardiography (STE) in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).
Patients and methods: Between June 2018 and July 2019, a total of 31 AAV patients (17 males, 14 females; median age: 53 years; range, 47 to 62 years) and 21 healthy controls (11 males, 10 females; median age: 56 years; range, 46 to 60 years) were included in the study. Clinical and biochemical characteristics of all participants were recorded. All participants underwent conventional and two-dimensional STE. The receiver operating characteristic (ROC) curve analysis was performed to determine the cut-off value of serum N-terminal prohormone of brain natriuretic peptide (NT-pro-BNP) that predicted subclinical left ventricular dysfunction. The Spearman correlation analysis was used to determine the correlation between left ventricular global longitudinal strain (LV-GLS) and NT-pro-BNP.
Results: The LV-GLS was lower in AAV patients (19.3% vs. 21.7%, respectively; p=0.014). NT-pro-BNP was negatively correlated with LV-GLS (p=0.005, r=0.401).
Conclusion: Subclinical left ventricular dysfunction can be detected by STE in patients with AAV who have free of clinically overt cardiovascular disease. The LV-GLS is negatively correlated with serum NT-pro-BNP levels.
Citation: Nur İzgi T, Barutcu Ataş D, Ataş H, Akaslan D, Ilgın C, Velioğlu A, et al. Prediction of subclinical left ventricular dysfunction by speckle-tracking echocardiography in patients with anti-neutrophil cytoplasmic antibody--associated vasculitis. Arch Rheumatol 2022;37(1):129-135.
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
The authors received no financial support for the research and/or authorship of this article.